Foundayo™ (orforglipron), a new oral GLP-1 pill for weight loss, is now available in the U.S. as a prescription medicine. It's designed to help adults with obesity or overweight individuals with weight-related medical issues lose excess body weight and maintain weight reduction alongside a reduced-calorie diet and increased physical activity. This once-daily pill can be taken without food or water restrictions, making it a convenient option for those seeking weight management support.
The medication's efficacy is supported by the rigorous ATTAIN clinical trial program. In the ATTAIN-1 trial, participants taking the highest dose of Foundayo lost an average of 27.3 pounds (12.4%) compared to 2.2 pounds (0.9%) with placebo. The treatment also led to reductions in cardiovascular risk markers, including waist circumference, non-HDL cholesterol, triglycerides, and systolic blood pressure.
However, it's important to note that Foundayo may cause tumors in the thyroid, including thyroid cancer. Symptoms to watch for include a lump or swelling in the neck, hoarseness, trouble swallowing, or shortness of breath. Patients should inform their healthcare provider if they experience any of these symptoms. Additionally, the medication may cause other side effects such as nausea, constipation, diarrhea, vomiting, indigestion, stomach pain, headache, swollen belly, fatigue, belching, heartburn, gas, and hair loss.
Foundayo is available via LillyDirect® and telehealth providers, with prices starting at $149 per month for self-pay patients. Commercially insured individuals may pay as little as $25 per month with the Foundayo savings card, and eligible Medicare Part D recipients may pay $50 per month. The medication is not recommended for use with other GLP-1 receptor agonist medicines, and it's not known if it's safe for use in children.
In terms of access, obesity remains a significant health issue, with approximately half of Americans with employer-sponsored insurance lacking coverage for obesity management medications. Eli Lilly is committed to expanding access and improving affordability, offering self-pay options for individual patients.
Overall, Foundayo represents a significant advancement in weight management, offering a convenient and effective treatment option for those struggling with obesity or overweight conditions. However, patients should be aware of potential side effects and consult with their healthcare provider to determine if Foundayo is a suitable choice for their individual needs.
